Pawr ELISA Kit for Mouse(Mus musculus) | EIAab.comPawr ELISA Kit for Mouse(Mus musculus)

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Pawr (Gene name),

PRKC apoptosis WT1 regulator protein (Protein name ), PAWR_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pawr(Par4);

Protein name:

PRKC apoptosis WT1 regulator protein;

Alternative:

Prostate apoptosis response 4 protein(Par-4);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with WT1, via the C-terminal region. Homooligomer. Interacts also with a wide variety of proteins, such as atypical PKCs, p62, DAPK3 kinase and THAP1. Interacts with actin, AATF, BACE1, SPSB1, SPSB2 AND SPSB4. Component of a ternary complex composed of SQSTM1 and PRKCZ.

Function:

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Subcellular Location:

Cytoplasm Nucleus Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies.

Protein Attributes:

Sequence length:

333

Sequence:

50:

100:

150:

200:

250:

300:

333:

DLLNRDLDDM | EDENEQLKQE | NKTLLKVVGQ | LTR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:114774

STRING:

10090.ENSMUSP00000092951

SMR:

Q925B0

String:

Q925B0

UniGene:

Mm.391419

Uniprot:

Q925B0

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ELISA Kit for Mouse PRKC apoptosis WT1 regulator protein

Cat.:

E15496h

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96T

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ELISA Kit for Mouse PRKC apoptosis WT1 regulator protein

Cat.:

E15496m

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96T

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ELISA Kit for Mouse PRKC apoptosis WT1 regulator protein

Cat.:

E15496r

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Packing:

96T

CLIA Kit for Mouse PRKC apoptosis WT1 regulator protein

Cat.:

U15496m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PRKC apoptosis WT1 regulator protein

Cat.:

U15496r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PRKC apoptosis WT1 regulator protein

Cat.:

U15496h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse PRKC apoptosis WT1 regulator protein

Cat.:

P15496Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse PRKC apoptosis WT1 regulator protein

Cat.:

P15496Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse PRKC apoptosis WT1 regulator protein

Cat.:

P15496Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse PRKC apoptosis WT1 regulator protein

Protein for Mouse PRKC apoptosis WT1 regulator protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A novel isoform of prostate apoptosis response 4 (PAR-4) that co-distributes with F-actin and prevents apoptosis in neural stem cells."
Wang G. , Silva J. , Krishnamurthy K. , Bieberich E.
Apoptosis11:315-325(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
strain: 129S4/SvJae.
2.

"Mouse par-4 cDNA sequence."
Han S.-S. , Rangnekar V.M.
Submitted (2006-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: C57BL/6.
3.

Hackett J.D.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 137-333 (ISOFORM 1)
strain: Swiss Webster / NIH.
4.

"RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice."
Xie J. , Awad K.S. , Guo Q.
J. Neurochem.92:59-71(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEUROSYNAPTIC DEGENERATION
5.

"The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues."
Masters S.L. , Yao S. , Willson T.A. , Zhang J.-G. , Palmer K.R. , Smith B.J. , Babon J.J. , Nicola N.A. , Norton R.S. , Nicholson S.E.
Nat. Struct. Mol. Biol.13:77-84(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPSB1; SPSB2 AND SPSB4

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